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Korean J Pancreas Biliary Tract > Volume 5(1):2000 > Article
The Korean Journal of Pancreas and Biliary Tract 2000;5(1):1-6.
만성 췌장염 환자의 대변 내 췌장 Elastase-1
이진헌1, 정재복1, 박윤희2, 서정훈1, 박승우1, 이세준1, 정준표1, 송시영1, 강진경1
1연세대학교 의과대학 내과학교실
2연세대학교 의과대학 소화기병 연구소
Fecal Pancreatic Elastase-1 in Patients with Chronic Pancreatitis
Jin Heon Lee1, Jae Bock Chung1, Yoon Hee Park2, Jeong Hun Suh1, Seung Woo Park1, Se Joon Lee1, Joon Pyo Chung1, Si Young Song1, Jin Kyung Kang1
1Departments of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
2Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
Corresponding Author: Jae Bock Chung ,Tel: 361-5412, Fax: 393- 6884 , 
ABSTRACT
Background/Aims:
Recently, fecal pancreatic elastase-1 assay was characterized as a another option for more accurate indirect pancreatic function tests in chronic pancreatitis. The aim of this study was to evaluate the clinical role of fecal pancreatic elastase-1 assay in patients with chronic pancreatitis.
Methods:
Fecal pancreatic elastase-1 was assayed in 16 patients with chronic pancreatitis. Nine healthy voluteers were studied as normal controls. We catagorized patients with chronic pancreatitis into two groups, mild/moderate (n=5) and severe (n=11), based on Cambridge grading by endoscopic retrograde cholangiopancreatography and the presence (n=7) or absence (n=9) of diabetes mellitus as a complication of chronic pancreatitis.
Results:
There was no difference for fecal elastase-1 between patients and controls. However, the fecal elastase-1 values in patients with severe chronic pancreatitis had a tendency to reduce than those in mild/moderate group although there was no statistically significant correlation. Furthermore, patients with diabetes mellitus as a complication of chronic pancreatitis showed lower fecal elastase-1 values, wherase those without diabetes mellitus did not. No association was found between reduced fecal elastase-1 and the etiology of chronic pancreatitis. Conclusion: Fecal elastase-1 concentrations were reduced in patients with severe chronic pancreatitis or diabetes mellitus as a complication of chronic pancreatitis.
Keywords: Chronic pancreatitis, Pancreatic elastase-1, ERCP, Cambridge grading
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