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Korean J Pancreas Biliary Tract > Volume 3(1): > Article
임상증상 및 종양표지자와 췌장암 절제가능성과의 관계
강인구, 이종균, 이규택, 이석호, 이풍렬, 김재준, 고광철, 백승운, 이종철, 최규완
성균관대학교 의과대학 삼성서울병원 내과학교실
The Relation of Clinical Symptoms and Tumor Markers with Resectability in Patients with Pancreatic Cancer
In Koo Kang, Jong Kyun Lee, Kyu Taek Lee, Suk Ho Lee, Poong Lyul Rhee, Jae-Jun Kim, Kwang Cheol Koh, Seung Woon Paik, Jong Chul Rhee, Kyu Wan Choi
Department of Internal Medicine, Sung Kyun Kwan University College of Medicine, Samsung Medical Center, Seoul, Korea
Corresponding author:  Jong Kyun Lee,
ABSTRACT
Background/Aims:
Resection rates of pancreatic cancer remain low even among paitents with operable in imaging studies such as ultrasonography, dynamic CT, angiography. The purpose of this study was to evaluate the relationship between nonimaging parameters and resectability in patients with pancreatic cancer. Method: From 1995 to 1998, seventy-nine patient with pancreatic cancer were evaluated retrospectively. 43 patients underwent curative resection. 36 patient received palliative operation (n=21) or were not operated (n=15) due to distant metastasis or definite angioinvasion. We analysed whether abdominal pain, back pain, anorexia, vomiting, weight loss, performance status, jaundice (bilirubin>3 mg/dl), CEA (>4 ng/dl), and CA19-9 (>100 U/ml) were related to resectability.
Results:
In univariate analysis, resectability was correlated with abdominal pain, back pain, vomiting, performance status, and CEA. In multivariate analysis, back pain, performance status, and CEA were significantly associated with resectability. Conclusion: Back pain, poor performance status, and elevated CEA level are ominous predictable factors of resectability in patients with pancreatic cancer.
Keywords: Pancreatic cancer, Resectability, Symptom, Tumor marker
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