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Korean J Pancreas Biliary Tract > Volume 2(1):1997 > Article
The Korean Journal of Pancreas and Biliary Tract 1997;2(1):44-50.
호산구 증가증과 피하지방 괴사를 합병한 만성 췌장염 1예
박종재, 이홍식, 김창덕, 류호상, 현진해
고려대학교 의과대학 내과학교실
A Case of Eosinophilia and Subcutaneous Fat Necrosis Complicated by Chronic Pancreatitis
Jong Jae Park, Hong Sik Lee, Chang Duck Kim, Ho Sang Ryu, Jin Hai Hyun
Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea
Corresponding author:  Chang Duck Kim,
The eosinophilia complicated by chronic pancreatitis is rare and develops in association with severe damage to neighboring organs such as pleural effusion, pericarditis, and ascites, as well as in association with pancreatic pseudocyst. Subcutaneous fat necrosis is a well-described, though rare, complication of chronic pancreatitis and usually presents as small, erythematous, tender subcutaneous nodule distributed mainly over the distal extremities. The pathogenesis of these rare complications of pancreatitis is unknown, but it is suggested that a factor induced by pancreatic inflammation causing the degranulation of mast cells and the subsequent release of eosinophilic chemotactic factor A, and/or delayed hypersensitivity to altered pancreatic proteins are responsible for eosinophilia. And, there are some evidences to suggest that pancreatic enzyme, especially lipase liberated from the inflamed pancreas plays a key role in subcutaneous fat necrosis. We report, here, a case of eosinophilia and subcutaneous fat necrosis associated with chronic pancreatitis.
Keywords: Eosinophilia, Subcutaneous fat necrosis, Chronic pancreatitis
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