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Korean J Pancreas Biliary Tract > Volume 2(2):1997 > Article
The Korean Journal of Pancreas and Biliary Tract 1997;2(2):135-140.
Cerulein에 의해 유발된 생쥐의 급성 췌장염에서 산소유리기의 역할과 α-tocopherol의 치료 효과
김용태, 류지곤, 윤용범, 최규완, 김정룡
서울대학교 의과대학 내과학교실 및 간연구소
Effect of α-tocopherol on Cerulein-Induced Acute Pancreatitis in Mouse
Yong-Tae Kim, Ji Kon Ryu, Yong Bum Yoon, Kyoo Wan Choi, Chung Yong Kim
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
Corresponding Author: Yong-Tae Kim ,
ABSTRACT
Studies in animal models suggest that oxygen-derived free radicals may be important in the pathogenesis of acute pancreatitis. Because α-tocopherol is an effective antioxidant in stabilizing unsaturated lipid against auto-oxidation, we investigated whether oxygen radicals play a role in cellular injury of cerulein-induced acute pancreatitis in mouse and whether α-tocopherol could ameliorate the course of pancreatitis. Cerulein was given into the peritoneal cavity in high dose (50 μg/kg/hr) over a period of 6 hours. α-tocopherol was given in a dose (10 mg/kg/day) over a period of 4 days before cerulein injections. Mice treated with α-tocopherol were found to have lower serum amylase levels compared with mice treated with cerulein alone. But there was not a significant difference in the degree of pancreatic edema between the pancreatitis group and α-tocopherol treated group. Pancreatic MDA levels of the pancreatitis group were elevated more than those of the control group. In conclusion, oxygen radicals may play a role on cellular injury of cerulein-induced acute pancreatitis in mouse, and α-tocopherol ameliorates the course of pancreatitis.
Keywords: Acute pancreatitis, Vitamin E, Oxygen-derived free radicals
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