1Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul, Korea 2Department of Anatomic Pathology, Korea University College of Medicine, Seoul, Korea
Corresponding author:
Chang Duck Kim,
ABSTRACT
Background/Aims: Several publications reported that intravenous or intraperitoneal administration of cerulein induced a edematous pancreatitis in rats. The present study was performed to elucidate the effect of cerulein administration route on the severity of pancreatitis in rat. Methods: Twenty-one male Sprague-Dawley rats(150-200 g) were studied. Pancreatitis was induced by intravenous infusion of 5 μg/hour/kg body weight of cerulein for 4 hours and by inteavenous infusion of 40 μg/kg body weight of cerulein at hourly intervals. After 1 hour postinjection, blood was drawn for biochernical studies including amylase, AST, ALT, total bilirubin and alkaline phosphatase. Pancreas was obtained to examine the severity of pancreatitis. Results: Cerulein by intravenous and intraperitoneal injection caused a edematous pancreatitis than in control pancreas. However, more severe edematous pancreatitis was seen in intravenous cerulein infusion group than intraperitoneal injection group. Amylase and alkaline phosphatase were significantly increased in edematous pancreatitis. Amylase was relatively higher in intravenous cerulein infusion group than intraperitoneal injection group. Conclusion: These results suggest that the severity of pancreatitis was less severe in intraperitoneal administration than intravenous administration of cerulein. Administration route of cerulein play a important role in the development of edematous pancreatitis in rats.
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