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Korean J Pancreas Biliary Tract > Volume 3(1): > Article
백서에서 Cerulein 투여 방법이 실험적 췌장염 발생에 미치는 영향
김광희1, 김창덕1, 김영식2, 이홍식1, 류호상1, 현진해1
1고려대학교 의과대학 내과학교실, 소화기연구소
2고려대학교 의과대학 병리학교실
The Effect of Intravenous and Intraperitoneal Administration of Cerulein in Experimental Pancreatitis in Rat
Kwang Hee Kim1, Chang Duck Kim1, Young Sik Kim2, Hong Sik Lee1, Ho Sang Ryu1, Jin Hai Hyun1
1Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul, Korea
2Department of Anatomic Pathology, Korea University College of Medicine, Seoul, Korea
Corresponding Author: Chang Duck Kim ,
ABSTRACT
Background/Aims:
Several publications reported that intravenous or intraperitoneal administration of cerulein induced a edematous pancreatitis in rats. The present study was performed to elucidate the effect of cerulein administration route on the severity of pancreatitis in rat.
Methods:
Twenty-one male Sprague-Dawley rats(150-200 g) were studied. Pancreatitis was induced by intravenous infusion of 5 μg/hour/kg body weight of cerulein for 4 hours and by inteavenous infusion of 40 μg/kg body weight of cerulein at hourly intervals. After 1 hour postinjection, blood was drawn for biochernical studies including amylase, AST, ALT, total bilirubin and alkaline phosphatase. Pancreas was obtained to examine the severity of pancreatitis.
Results:
Cerulein by intravenous and intraperitoneal injection caused a edematous pancreatitis than in control pancreas. However, more severe edematous pancreatitis was seen in intravenous cerulein infusion group than intraperitoneal injection group. Amylase and alkaline phosphatase were significantly increased in edematous pancreatitis. Amylase was relatively higher in intravenous cerulein infusion group than intraperitoneal injection group. Conclusion: These results suggest that the severity of pancreatitis was less severe in intraperitoneal administration than intravenous administration of cerulein. Administration route of cerulein play a important role in the development of edematous pancreatitis in rats.
Keywords: Cerulein, Administration, Pancreatitis, Rat
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