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Korean J Pancreas Biliary Tract > Volume 17(2):2012 > Article
The Korean Journal of Pancreas and Biliary Tract 2012;17(2):61-66.
다발성 원격 전이를 동반한 췌장암으로 오인된 췌장의 세로토닌 생성 신경내분비종양 1예
박선만, 고동희, 김영진, 한정완, 최민호, 장현주, 계세협, 이진
한림대학교 의과대학 한강성심병원 내과학교실
A Case of Pancreatic Serotonin-Producing Neuroendocrine Tumor Mimicked Pancreas Cancer with Multiple Distant Metastasis
Sun Man Park, Dong Hee Koh, Young Jin Kim, Jung Wan Han, Min Ho Choi, Hyun Joo Jang, Sea Hyub Kae, Jin Lee
Department of Internal Medicine, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea
Pancreatic serotonin-producing neuroendocrine tumors(NETs) are exceedingly rare tumors that originate from the enterochromaffin cells of the pancreatic neuroendocrine system. Although pancreatic serotonin-producing NETs grow slowly and show an indolent clinical behavior, they are potentially malignant. Due to the late onset of clinical symptoms and delayed diagnosis of the tumor, there was a high incidence of distant metastases and an unfavorable overall prognosis. The diagnosis of pancreatic serotonin-producing NETs should be based on the measurement of serotonin in serum or its demonstration in the tumor and/or by the measurement of 5-Hydroxyindoleacetic acid(5-HIAA) in urine. We experienced a rare case of pancreatic serotonin-producing NET mimicked pancreas cancer with multiple distant metastasis and report here with literature review.
Keywords: pancreas, neuroendocrine tumors, serotonin
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