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Korean J Pancreas Biliary Tract > Volume 16(2):2011 > Article
The Korean Journal of Pancreas and Biliary Tract 2011;16(2):154-159.
반복적인 급성 췌장염으로 발현된 담도상피내암종1예
김대용, 박상현, 안평, 김연수, 윤재훈, 석기태, 김진봉, 최영희1
한림대학교 의과대학 내과학교실, 1병리학교실"
A Case of Biliary Intraepithelial Neoplasia Presented with Recurrent Acute Pancreatitis
Dae Yong Kim, Sang Hyun Park, Pyoung Ahn, Yeon Soo Kim, Jai Hoon Yoon, Ki Tae Suk, Jin Bong Kim, Young Hee Choi1
Departments of Internal Medicine and 1Pathology, Hallym University College of Medicine, Chuncheon, Korea
ABSTRACT
Biliary intraepithelial neoplasia (BilIN) and intraductal papillary neoplasm of the biliary tract (IPN-B) were suggested the premalignant conditions of cholangiocarcinoma. BilIN microscopically manifests as flat, pseudopapillary or micropapillary lesions. In contrast, IPN-B is grossly visible, and is characterized by prominent papillary proliferation with distinct fibrovascular cores. A 65 years old woman was diagnosed the recurrent acute pancreatitis of uncertain etiology, 4 times, during the past 5 years. At the last admission, abdominal computed tomography revealed a tiny stone in the distal common bile duct. We performed an endoscopic retrograde cholangiopancreatography, and studies revealed a filling defect on distal CBD without evidence of CBD stone and a suspicious of soft tissue mass in the ampulla. We obtained biopsy specimens at the ampulla and distal CBD by biopsy forceps under the fluoroscopic guidance. The pathological report demonstrated BilIN. Therefore, we report a case of BilIN presented with recurrent acute pancreatitis with brief review.
Keywords: Biliary intraepithelial neoplasia, Recurrent acute pancreatitis
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